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JAMA Neurol 81:5968

This therapy-induced PSMA overexpression establishes a self-amplifying targeting cyclethe mechanism that potentiates Psa-ARs selective tumor accumulation through PSMA-mediated endocytosis, creating a positive feedback loop between target engagement and drug delivery efficiency

Oxidative glutamate toxicity in HT22 cells involves the inhibition of the glutamate/cystine antiporter, a subsequent depletion of glutathione, an increase in ROS production, a consecutive impairment of mitochondria, and an influx of Ca 2+ , which ultimately leads to neuronal cell death 25,26,27,31

This converging evidence suggests that the timing and composition of the early diet are critical environmental determinants

(2019) 156:195168.e1