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Are high doses of vitamin A safe

In all, persistent tissue injury provokes chronic inflammation and an increase of pro-fibrotic factors, such as TGF-1, ROS, PAI-1, ROCK, TNF, and TIMPs, which induce the phenotype transformation of precursor cells to myofibroblasts

The reduced flux through the oxidative phosphorylation pathway also carries forward to the electron transport chain at the inner mitochondrial membrane