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Vitamin A is necessary for many physiological activities, including vision, development, prenatal growth and development, immunologic competency, cell division, proliferation of cells and a process called apoptosis, maintenance of epidermal tissue, and cognitive function [52]

Likewise, preclinical and emerging clinical body composition work is encouraging, but claims of muscle preservation require complete human data and functional outcomes

sustained growth-hormone-axis stimulation also carries a theoretical, class-wide concern for worsened insulin resistance, a recognized effect of excess growth hormone exposure generally Evidence snapshot: The strongest available evidence is a small 1997 randomized, placebo-controlled human trial (19 adults aged 55-71) testing a closely related GHRH(1-29) analog over 16 weeks, which found increased IGF-1 in both sexes, a significant lean-mass increase in men only, and increased skin thickness in both sexes

Cycling is precautionary given limited long-term data, it reduces theoretical risk of receptor desensitization

However, oxidative stress and associated decreases in levels of glutathione (GSH) are known to play a central role in ALD