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Reactions were performed with 0.001 mg/ml DNA substrate Poly(dI-dC), 1 M radiolabelled S-adenosyl-L-[methyl-3H] methionine (SAM) co-substrate, and recombinant human DNMT1 enzyme

These patients develop peripheral neuropathies thought to arise from transient deficiency of vitamins B 6 and B 12 as judged by a favorable response to concomitant supplementation with these micronutrients (Muller et al., 2013)

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