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In addition to regulating insulin and insulin-like growth factor signaling pathways, these factors are also involved in the control of autophagy and proteasome activity key mechanisms responsible for the degradation of damaged or oxidized proteins

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Similar to the results from the binding and dimerization experiments the Cys 2 and Tyr 2 analogs exhibited marked inhibitory activity

Specific occlusion syndrome induction can be performed by the occlusion of a major vein (Vukojevic et al., 2018