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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

Folate (Vitamin B9) is particularly important for women of childbearing age

leads to pancreatic islet cell damage, whereas the db/db mouse model is deficient in leptin receptors

B FDA Review 04

Live imaging was conducted at intervals of 5 ~ 6 days to monitor the progression of the disease