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doi:10.1016/S0072-9752(08)02130-1

AOD vs GLP-1 GLP-1 agonists (semaglutide, tirzepatide) are our primary medical weight-loss lane with the strongest evidence

Disclosures: Lita Petcharaporn: Nothing to Disclose, Fatma Barakat: Nothing to Disclose, Nothing to Disclose, Tarek Hassanein: Nothing to Disclose 980 THE PNPLA3 I148M VARIANT AGGRAVATES INFLAMMATION IN MACROPHAGES THROUGH IMPAIRED NUCLEAR RECEPTORS (LXR ALPHA, PPAR GAMMA, AND GR ALPHA) SIGNALLING Emmanuel Dixon 1 thierry claudel 1 Jakob-Wendelin Genger 1 Ci Zhu 1 Alexander Nardo 1 Veronika Mlitz 1 Claudia Fuchs 1 Andreas Bergthaler 1 Paola Dongiovanni 2 Wilfried Ellmeier 1 Michael Trauner 1 , 1 Medical University of Vienna, 2 Maggiore Policlinico, Milan Background: Most functional studies linking the single nucleotide polymorphism (rs738409