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After thawing, cells were filtered through EASYstrainer 40 m (Greiner), washed with PBS and cultivated in RPMI-1640 (Gibco) supplemented with 10% fetal bovine serum (FBS-12A, Capricorn Scientific), 200 U/mL penicillin and 200 g/mL streptomycin (Gibco)

No increase in number of adverse events with increasing renal or hepatic impairment was observed, and no new safety or tolerability findings with cagrilintide were identified with renal or hepatic impairment

Because the antibody titer was not normally distributed based on Levenes test, non-parametric KruskalWallis and MannWhitney tests were used to assess the statistical differences between groups

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Derartige Zellvernderungen knnen fatale Auswirkungen haben