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In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)

In addition to COX , NRF2 is widely involved in the regulation of the expression of other OXPHOS-related nuclear genes, including three of the four subunits of succinate dehydrogenase ( SDH , complex II) and mitochondrial transcription factors ( TFAM and TFB1/2M )

However, a direct comparison between both experiments is not recommended and further research is needed to elucidate the transcription-translation dynamics of the investigated biomarkers in long COVID-associated persistent VCD

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