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3.7 Nomogram model performance We constructed a two-gene nomogram based on the hub genes SP1 and SEPHS2 to predict age-related risk, with the risk score calculated as: Risk Score = 4.9784 SP1 5.0982 SEPHS2

Usually, the first follow-up visit is planned within 6 months from diagnosis and then every 1224 months (every 36 months if complications occur) is adequate to confirm compliance with the GFD, rule out the onset of autoimmune diseases and metabolic changes, and, most importantly, to allow for the early diagnosis of any complications [163]

However, complete recovery may take several months, particularly if the deficiency has been present for a long time