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In SURMOUNT-1, tirzepatide produced large average body-weight reductions over 72 weeks, with higher doses associated with greater weight loss

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Likewise, elevated GH in patients with poorly controlled T1DM was also shown to promote diabetic nephropathy in these patients

Several randomized placebo-controlled trials on rhGH-replacement therapy in children and adults showed significant increases in serum calcium and urinary calcium concentrations in rhGH-treated patients