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Comment: Commenters requested that we provide an exclusionary list of predisposing conditions to cardiovascular disease or a list of compounding risk factors that may put patients at increased risk for future ASCVD diagnosis since there may be a wide range of severity and complexity of the beneficiaries' risk factors

Combinations of gonadotropins have been found to be equally effective for treating hypogonadotropic hypogonadism, and are less expensive and less invasive than pulsatile GnRH therapy

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The review article details analytical challenges such as heterophilic antibodies, pituitary HCG in peri and postmenopausal women, and variant forms that may cause false positive or negative results, guiding assay design and interpretation

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