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[DOI] [PubMed] [Google Scholar] 168.Rahimpour Z., Hoseini R., Behpour N

Inhibiting SLC7A11, genetically or chemically, leads to cysteine deprivation and reduces AML cell viability and self-renewal by promoting ferroptosis, while upregulation of SLC7A11 by the small molecule drug APR-246 enhances cystine uptake and detoxifies lipid peroxides, protecting cells from ferroptotic death (146,147)

It was confirmed that astrocytes viability was not affected by PURE G4 -LA 12 -anti- GLS1 -siRNA (Fig

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