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Materials and methods Cell lines The cell lines of 786-O, 769-P, A498, ACHN, CAKI-1, G401, U2OS, and HEK293T cells were obtained from the American Type Culture Collection

41589_2021_915_MOESM8_ESM.mpeg Supplementary Video 6 Representative movie for 100 ns water-free MD simulation of GPX4 R152H

However, a preliminary study showed that if diagnosed in the subclinical stage, treatment with penicillamine (200 mg total dose PO BID for 4 months) lowered hepatic copper content and improved hepatic histopathology

Leucovorin is a folate-based medication traditionally used in medicine (for example, as a rescue drug with certain chemotherapies), and now its being studied for autism

All animals were monitored weekly for body weight (BW), food and water consumption