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188 VascellariS.MelisM.PalmasV.PisanuS.SerraA.PerraD.et al (2021)

Reducing the secretion of IL6 in elderly, either by (a) administration of sex steroids, (b) decreasing fat through diet and exercise, (c) improving nighttime sleep, and (d) controlling adequately chronic pain and inflammation with nonsteroidal antiinflammatory agents, may improve sleep, daytime alertness, and performance, and decrease the risk of common ailments of old age, e.g., metabolic and cardiovascular problems, cognitive disorders, and osteoporosis (118, 149, 150)

The mitochondrial basis of aging

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Macrophages, for instance, shift from the M1 (pro-inflammatory) state to the M2 (anti-inflammatory, tissue-repair) state