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The respective ligand was modeled into this density using pre-existing monomers in the CCP4 library for 1 , E-64c and E-64d and a custom ligand built using Coots ligand builder for (2 S ,3 S )- t -ES- a9 - b7 (ref

10.1038/s41598-021-84501-5 53 ChenQ.CheC.LiuJ.GongZ.SiM.YangS.et al (2022)

The figure also shows the net reaction: -ketoacid + CoASH (coenzyme A) + NAD + acyl-CoA + CO 2 + NADH + H +

While D2C7 monotherapy has demonstrated prolonged survival and promoted disease control in some patients, its efficacy is constrained by the potent immunosuppressive microenvironment in GBM [682]