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It also increases integrin expression and the transcription factor p63, both of which support the proliferative and synthetic activity of dermal fibroblasts

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We observed that induction of R175H expression in OVCAR5 cells resulted in a more significant reduction in cell proliferation upon treatment with APR-246 (Fig

Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ (2011) Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy