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J.Vilella-AntnM

While these research directions and treatment methods have shown some efficacy in improving IRI outcomes, a significant gap still exists between basic research and practical clinical applications

This affects calcium-sensitive organelles such as the mitochondria and endoplasmic reticulum [163] and causes the release of calcineurin and calpains, mediators of cell death [164]

As a result, certain ethnic populations may require increased administration of PGP antagonist in the formulation of the present invention to arrive at the an efficacious dose of the therapeutic (e.g., those from African descent)