glutathione reductase and oxidative stress Frontiers Role of G6PD in managing

An imbalance in glutathione metabolism, defined by lower GSH:GSSG, has been linked to a number of chronic diseases including feline chronic renal failure (Reference Keegan and Webb43) and in humans, cancer, neurodegenerative disorders, cystic fibrosis, viral infection, diabetes mellitus, renal failure and liver disease (Reference Wu, Fang and Yang44)

This has led to a growing body of literature investigating zincs cellular metabolism, particularly the functions of zinc transporters and storage mechanisms during cancer progression

Figure: Disulfide Oxidizing Agents - b-mercaptoethanol, dithiothreitol, and phosphines Figure: TCEP reduction of disulfides The inside of cells are maintained in a reduced environment by the presence of many "reducing" agents, such as the tripeptide g-glu-cys-gly (glutathione)

They confer protection by acting through the G-Coupled Protein Receptors (GCPR) (Jarosz et al., 2017)

Doi:10.3390/cosmetics2030236