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Eur J Clin Invest 2011;41:291298.ArticlePubMed 6

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Induction is problematic in drug development and an undesirable characteristic for a drug, thus drugs that have Phase II metabolism as their primary route of elimination may be easier to develop

The German BfArM and equivalent agencies (ANSM in France, AEMPS in Spain, AIFA in Italy, URPL in Poland) treat unauthorized human use of these compounds as outside the scope of the marketing authorization regime entirely

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