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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

Combination Research Some researchers investigate tesamorelin in combination with GHRP (Growth Hormone-Releasing Peptide) compounds like Ipamorelin to study comprehensive GH axis stimulation: Frequently Asked Questions Is tesamorelin FDA approved