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The result is a molecule with 600-fold reduced IGFBP affinity and approximately 3-fold greater potency at the IGF-1 receptor in cell-culture assays

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Yanke, A

The corresponding NMA results are presented in Table 4 and Figure 2: glutathione and amifostine present notable superiority compared to the placebo in preventing severe neurotoxicity (glutathione: OR = 0.19, 95% CrI: 0.040.64