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In some embodiments, the improvement in oxidative-phosphorylation leads to augmented cellular ATP production and/or metabolism

Assay protocols were done in alignment with manufacturers instructions, and these evaluations were adjusted to protein content quantified based on the Bradford assay [37]

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Among the macrophage populations in obese adipose tissue, lipid-associated macrophages (LAM) form a cluster with a distinct transcriptional signature related to lipid metabolism and phagocytosis, and their numbers increase during the progression of obesity