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Age: Younger individuals may see faster results due to better skin regeneration and metabolic efficiency

Biochemistry 49(39):84998511 Ernst IM, Schuemann C, Wagner AE, Rimbach G (2011) 3,3-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts

Recent studies suggest that astrocytes play even more active roles in repairing injured brain, as reactive astrocytes in a damaged brain are shown to de-differentiate into stem-like cells and re-differentiate into neurons [67,68]

For instance, biliverdin, a product derived from HO-1, along with the subsequent bilirubin, possesses antioxidant properties that can counteract lipid peroxidation [89]