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TamuraREde VasconcellosJFSarkarDLibermannTAFisherPBZerbiniLF

The researchers found that the rate of brain atrophy was considerably slower in the B-vitamin group compared with the control group

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3.2 CB-839 exposure leads to mitochondrial ROS accumulation in CLL cells Considering that glutathione is the main antioxidant that provides protection from excessive ROS production, we evaluated the consequences of glutathione synthesis inhibition on cellular ROS for 4 hours and mitochondrial SOX accumulation for 24 hours after incubation with CB-839 ( Figures 1E, G )

*Correspondence: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology