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Alprostadil can lead to side effects like bleeding or bruising at the injection site, pain or burning in the penis or surrounding tissues, headache, back pain, or vision changes

M.AbrahamE.et al (2004)

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Lead compounds can be optimized through principles such as bioisosterism, prodrugs, quantitative structure-activity relationships (QSAR), and 3D-QSAR, followed by in silico ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) prediction and physiologically-based pharmacokinetic simulations for preclinical testing

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