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A broader 2023 review of microneedle-mediated delivery put the overall range of reported pore-closure times from a few hours up to 72 hours, depending heavily on skin type, needle dimensions, occlusion, and formulation

The formation of ceramide-induced pores has been associated with interactions between ceramides and proteins such as Bax or the voltage-dependent anion channel (VDAC), which facilitate cytochrome c release and initiate apoptosis (Siskind et al., 2006

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