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Description

Hence, it is logical to hypothesize that masking of the terminal NH 2 group by making a labile chemical derivative of INH, i.e., a derivative which can release INH back when exposed to biofluid in gut or blood (owing to hydrolytic activity of esterase/amidase) can limit known metabolic biotransformations of INH (Figure 6)

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10.3389/fphar.2022.873646 237 YeS.MaoB.YangL.FuW.HouJ

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The Dialcat Consortium Article: PLOS ONE

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The most effective tools are the ones that people remember, because they are more likely to use them

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It is metabolized hepatically and excreted renally, with a half-life of under thirty minutes

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