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Moreover, in conditions not directly caused by flavoprotein gene mutationssuch as L-2-hydroxyglutaric aciduria (L2HGA) or Friedreichs ataxia (FRDA)metabolic pathology often involves secondary dysfunction of FAD-dependent enzymes and redox disruption

doi: 10.1016/j.phymed.2010.03.012, 211

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If the qi and blood are harmony and smoothness, the brain will be awake and have intelligent mind, menstruation mediated by the uterus will be normal, thus, these indicated that the liver has the functional relationships with the brain and the extraordinary fu organs

Mitochondrial production of ROS also plays a key role in oxidative stress (Madamanchi and Runge, 2007), so one would predict that estrogen may also have an important impact on vascular oxidative stress