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Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

The principle is based on the different membrane permeability to the membrane-impermeable fluorescent DNA intercalating agent PI which stains membrane-compromised cells (red fluorescence) [40]

Novel formation of nitroxide radicals by radical addition to nitrones

The sulfhydryl group (-SH) on glutathione's cysteine residue binds directly to heavy metals including mercury, lead, cadmium, and arsenic, forming glutathione-metal conjugates that can be excreted through bile and ultimately eliminated from the body

doi: 10.1038/s41467-019-13114-4 51 BlackerTSDuchenMR