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A B12 deficiency can cause a surprisingly wide range of bizarre symptoms beyond just feeling tired

Re-measuring the sample on a different platform can expose a method-specific artifact

A 2021 Nature Communications study then showed that MOTS-c is induced by exercise and that treating mice, including animals started late in life, boosted running capacity and physical performance across young, middle-aged, and old groups [3]

Clinical interpretation still depends on the individual case

That said, the clearest human evidence so far is a small pilot where three months of B12 brought deficient older adults strength up to match non-deficient peers promising, but larger trials are the next step, especially on whether B12 supplementation helps people who arent prone to deficiencies