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The checkpoint inhibitor agents included in the study were CTLA-4 inhibitors, PD-1 inhibitors, PD-L1 inhibitors, and combination treatment with a CTLA-4 inhibitor (ipilimumab) and a PD-1 inhibitor (nivolumab)

The organic layer was dried over Na 2 SO 4 , evaporated under reduced pressure to get the crude mixture which was chromatographed on silica gel (100-200 mesh) using 20-80% EtOAc in petroleum ether as eluent to give #I8 as a yellow solid (3.8 g, 48%)

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Supports Antioxidant Defense Glutathione plays a central role in protecting cells from oxidative stress.*

Targets Visceral Fat : By stimulating the metabolic breakdown of stored fat, IGF-1 LR3 can be particularly effective at reducing visceral fat (fat around organs), which is crucial for metabolic health