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The nervous and immune systems need vitamin B6 to function efficiently, and it also is needed for the conversion of tryptophan (an amino acid) to niacin (a vitamin)

J Periodontal Res 1966

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Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations, we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD+ salvage cycle

One potential disadvantage is that peptide therapy may not produce instant results