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Safety and tolerability: Extensive safety research on both individual peptides and the combination shows excellent tolerability minimal adverse effects, no major organ toxicity, no hormonal disruption, and no serious adverse events across thousands of research uses

However, a subgroup analysis of 655 breast cancer patients from the study that were not on chemotherapy reduced the hazard ratio (HR) for recurrence over 10 years by 35% (HR = 0.65, 95% confidence interval 0.411.04, P = 0.035) [294], making celecoxib a viable option as an adjunct therapy

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