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Furthermore, excessive copper in chicken liver cells leads to varying degrees of nuclear membrane damage, mitochondrial swelling and vacuolization, upregulation of caspase-3, cytochrome c, Bax, and Bak1 expression, downregulation of Bcl2, and increased expression of P53, indicating that copper may induce cell apoptosis by damaging mitochondria (136)

therefore, findings in the subgroup receiving both drugs need to be interpreted cautiously, Dr

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Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease