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10.1016/j.cell.2020.05.012 102

as expected from the dynamics of ceruloplasmin and zinc binding with copper, an interesting marginal inverse SEM covariance was noted between ceruloplasmin (Cp) and caseness ( n = 134, z = 1.87, P = 0.062) and % free Cu/zinc ratio is equally inversely covariant with ceruloplasmin (Cp) ( n = 134, z = 3.58, P = 0.000) and with plasma zinc ( n = 134, z = 3.37, P = 0.001)

(40, 41) The group that supplemented with selenium during their pregnancy as well as postpartum, showed a decrease in the progression of autoimmune thyroiditis, including a reduction in TPO antibody levels