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Its role in detoxifying harmful substances in the liver and supporting immune function is well-documented

In fact, as a NO-dependent post-translational modification of proteins, S-nitrosothiols levels have been used as an indicator of NO production in biological samples and are known to increase upon infusion with sodium nitrite [140], nitrate ingestion [141], treatment with NO-releasing aspirin [142], and dietary flavonoid consumption [143]

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Consequently, SAM might serve as a sensor for the nutritional condition of the cell and epigenetically modify the expression of genes that affect hunger, glucose metabolism, and lipogenesis