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[21] When treated with cyanocobalamin, patients with Leber's disease may develop serious optic atrophy, possibly leading to blindness, based on few case reports

The freezer's temperature should be well below 32F or 0C

If clinical suspicion remains, targeted HIV enzyme-linked immunosorbent assay (ELISA) and hepatitis C serology (HCV Ab, HCV RNA) could be considered

Results, reported in 2007, showed no statistically significant difference between AOD-9604 and placebo for the primary endpoint of weight reduction at 24 weeks