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Once activated, the SMAD family member 4 (SMAD4) enters the nuclei and regulates the expression of genes inhibiting myoblast proliferation and differentiation, such as paired Box 3 (Pax3) and MyoD [120]

(80) demonstrated that Prevotella populations, previously associated with colitis in animal studies, can worsen intestinal inflammation and potentially lead to systemic autoimmune responses condition ( Prevotella has been linked to mucosal sites with inflammation and increase in T-helper type 17 cells mediating this process (81)

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Efficacy and safety of opicinumab in participants with relapsing multiple sclerosis: a randomized, placebo-controlled, phase 2 trial (AFFINITY part 1)