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elegans , a temperature-sensitive mutation also was inserted into the worm DNA along with the DNA of human A42 such that any foreign DNA would be destroyed but at elevated temperature the foreign DNA could be translated and the mRNA transcribed

When examining the relationship between lipids and synapses in various diseases, articles that focused solely on cholesterol in AD without also addressing synaptic dysfunction were excluded

In another preferred embodiment of the invention, the ligand is conjugated or synthesized via the C-terminal amino acid residue, i.e

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PGE1 enhances symptoms and nerve conduction velocities in DPN patients, particularly when combined with neuroprotective agents, such as methylcobalamin