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FEBS Lett 554(3):417421

These should encompass well-designed in vitro and in vivo studies alongside large-scale, multicenter randomized controlled trials with extended follow-up periods, diverse patient populations, and standardized dosing and formulation strategies

On the other hand, in a study carried out in hypercholesterolemic patients both pravastatin and atorvastatin showed no effect on cholesterol efflux (Khera et al., 2011)