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The main barriers to the widespread use of EDs include poor palatability, high out-of-pocket cost, and lack of provider awareness

NAD+ is a large molecule that cannot cross cell membranes in its whole form

It is also essential for folate and related one-carbon metabolism, where FAD is required as a cofactor for methylenetetrahydrofolate reductase (MTHFR), a key folate-metabolizing enzyme