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3.6 Neutrophils Neutrophils are a crucial component in the TME, exhibiting significant phenotypic and functional heterogeneity to either exert antitumor effects or promote tumor progression via multiple mechanisms

Ding Z, Han Y, Liu W, Zhang W, Xie Z, Zhou P, Jiang S, Lu J, Li J, Li Y, Ji M, Xue H, Tang J, Wang Z, Xia K, Li D, Wu J, Wang Y, Kim LM, Naseem DF, Li G, Zafereo ME , Yao C, Tao Y, Zha X, Liu Y

Espinosa, R

These findings suggest that repetitive element methylation may be less sensitive or not consistently altered by NS exposure compared to specific gene methylation 227