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It doesn't treat the supplement like a foreign protein to be digested

Due to the significant role of the nitro group of KAM-2 in HO-induced nucleophilic attack, a non-nitro analog, KAM-7, which is resistant to HO, was synthesized as a negative control

10.1186/s12951-025-03509-5 94 ZhouL.SunJ.LuT.ZhangX.WangM.XuY.et al (2025)

Tetrahydrobiopterin turnover in cultured rat sympathetic neurons: developmental profile, pharmacologic sensitivity, and relationship to norepinephrine synthesis