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The accumulation of damaged DNA in the cytoplasm, which serves as a damage-associated molecular pattern (DAMP) to be recognized by DNA sensors, including the cGAS-STING pathway, is observed in aging cells

Chiu, H.-Y., Yeh, T.-H., Huang, Y.-C

3 PehrssonPRRoselandJMPattersonKYPhillipsKMSpungenJHAndrewsKWet al

Inhibition of NOX4 with Setanaxib has been shown to normalize the stroma and restore T-cell infiltration, overcoming resistance to anti-PD-1 therapy [206]