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In vitro , 10 g/ml paeoniflorin can stimulate the synthesis of melanin, and its mechanism is to increase the protein level of MITF and its downstream TRP-1 by promoting the phosphorylation of ERK and CREB ( 2 O 2 -induced PIG1 and PIG3V cells from oxidative stress by activating JNK/Nrf2/HO-1 signaling pathway, including decreased ROS level and increased SOD, CAT, Nrf2 and HO-1 expression