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M1-like TAMs suppress sprouting angiogenesis and induce vessel maturation by secreting anti-angiogenic cytokines, such as interleukin (IL)-12 and TNF- 47,48

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Therapeutic use of statins, including simvastatin (Zocor), pravastatin (Pravachol), lovastatin (Mevacor, Altocor, Altoprev), rosuvastatin (Crestor), and atorvastatin (Lipitor), has been shown to decrease circulating coenzyme Q 10 concentrations (112-121)