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Conversely, Helional activates OR2J3 on A549 cells, triggering PI3K pathway activation, which leads to apoptosis and proliferation inhibition (72), highlighting the differential effects of ligands on the same receptor in different cell types

PKA phosphorylates numerous substrates, while EPACs act as GEFs catalyzing the conversion of the small GTPases Rap1 and Rap2 from an inactive (GDP-bound) to an active form [guanine triphosphate (GTP)-bound] (16)