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NICE stands for National Institute of Health and Care Excellence

Dysregulated iron homeostasis amplifies ferroptotic susceptibility through Fenton chemistry-driven lipid peroxidation and polyamine synthesis via the ODC1-MYC axis, a metabolic and oxidative cascade prominently observed in the inflamed synovium of rheumatoid arthritis ( Inducing ferroptosis in specific cell populations using agents like Imidazole ketone erastin (IKE) can suppress synovial fibroblast proliferation and inflammation (104)

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Unlike gels, which rely on diffusion across the cornea and conjunctivaoften resulting in low bioavailability and the need for frequent administration, MNs create microchannels that enhance drug permeability, ensuring optimal therapeutic outcomes [62]