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Furthermore, spermidines impact on neurogenesis and synaptic plasticity suggests its potential to mitigate age-related cognitive decline and improve memory function in both animals and humans (Reference Schwarz, Horn and Benson19)

A key event is the blood-retinal barrier disruption, with loss of pericytes and endothelial cells, leading to microaneurysms, increased vascular permeability, and capillary obstruction, resulting in poor oxygen distribution in the retina (Wang and Lo, 2018

It's one of the more interesting molecules in the longevity space because it works on a metabolic pathway that training and diet alone can't fully address

2004;287(4):L774-L783